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A complex rearrangement involving cryptic deletion of ETV6 and CDKN1B genes in a case of childhood acute lymphoblastic leukemia

✍ Scribed by Aleksandra Drago Krstic; Luciana Impera; Marija Guc-Scekic; Nina Lakic; Dragan Djokic; Bojana Slavkovic; Clelia Tiziana Storlazzi


Book ID
113513614
Publisher
Elsevier Science
Year
2009
Tongue
English
Weight
543 KB
Volume
195
Category
Article
ISSN
0165-4608

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Deletion of the 9p21 chromosomal region is frequently found in childhood acute lymphoblastic leukemia (ALL). The target of these deletions is CDKN2A, a gene encoding both p16(INK4a) and p14(ARF). However, contiguous genes such as CDKN2B, encoding p15(INK4b), or MTAP, encoding methylthioadenosine pho