BCL6 rearrangement and mediastinal involvement in a case of B cell acute lymphoblastic leukemia
β Scribed by Rubnitz, J E; Abushullaih, B; Kaste, S C; Raimondi, S C; Sandlund, J T; Pui, C-H; Behm, F G
- Book ID
- 110053882
- Publisher
- Nature Publishing Group
- Year
- 1998
- Tongue
- English
- Weight
- 109 KB
- Volume
- 12
- Category
- Article
- ISSN
- 0887-6924
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of a de novo Ph in T-cell acute leukemia. So this case could be the first de novo T-cell childhood ALL showing the expression of p210 protein associated with a very aggressive clinical evolution.
## Abstract __MLL__ (also known as __ALLβ1, HTRX__, or __HRX__) gene translocations are among the most common chromosomal abnormalities recognized in both Bβlineage acute lymphoblastic leukemia (ALL) and acute myeloid leukemia (AML). However, __MLL__ gene rearrangements are uncommon in Tβcell ALL.