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A comparison of ligand-induced redistribution of surface immunoglobulins, alloantigens, and concanavalin A receptors on mouse lymphoid cells

✍ Scribed by Christopher W. Stackpole; Lawrence T. DeMilio; Janet B. Jacobson; Ulrich Hämmerling; Michael P. Lardis

Publisher
John Wiley and Sons
Year
1974
Tongue
English
Weight
543 KB
Volume
83
Category
Article
ISSN
0021-9541

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✦ Synopsis

Abstract

Redistribution of surface immunoglobulins (Ig), H‐2^b^, Thy‐1.2 and TL. 1,2,3 alloantigens, and concanavalin A (Con A) receptors on mouse thymus, lymph node and spleen cells into “caps” induced by bivalent antibodies or ligands was compared by immunofluorescence. Surface Ig was capped rapidly following attachment of anti‐Ig antibody at 37°. Capping of alloantigens and Con A receptors occurred very slowly following attachment of alloantibody or Con A, but much more rapidly after addition of a secondary bivalent antibody. An inverse relationship between the number of surface component sites per cell and the extent of capping of that component was observed. Capping of alloantigens sparsely represented on the cell surface was not inhibited by high concentrations of alloantibody, in contrast to capping of alloantigens present in greater quantities. These results suggest that factors in addition to molecular cross‐linking may be involved in ligand‐induced redistribution of cell surface components.

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