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Studies on the ultrastructure of concanavalin a receptor sites at the surface of normal cells and cells transformed by oncogenic viruses

✍ Scribed by G. Torpier; L. Montagnier

Publisher
John Wiley and Sons
Year
1973
Tongue
French
Weight
963 KB
Volume
11
Category
Article
ISSN
0020-7136

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✦ Synopsis

Abstract

The distribution of receptor sites for Concanavalin A at the surface of hamster fibroblasts BHK 21/13 transformed by RNA or DNA oncogenic viruses, has been studied at the ultrastructural level by the Concanavalin‐peroxydase method, in connexion with the agglutinability of these cells. The product of the lectin‐bound peroxydase activity has the same thickness in all clones studied. In some transformed clones, the observed reaction is more irregularly distributed than in the original untransformed clone. These changes are however not always accompanied by changes of agglutinability. Moreover, such an irregular distribution has also been found in normal cells from other species. It is concluded that the surface alteration detected by the peroxydase method cannot be considered at the present time as a general transformation character.

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