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A central anti-DNA idiotype in human and murine systemic lupus erythematosus

✍ Scribed by Dan Eilat; Ruth Fischel; Avinoam Zlotnick

Book ID
102824141
Publisher
John Wiley and Sons
Year
1985
Tongue
English
Weight
939 KB
Volume
15
Category
Article
ISSN
0014-2980

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Systemic lupus erythematosus (SLE) is regarded as a classical autoimmune disease. Despite this belief, no one has been able to induce the disease in naive animals, neither with DNA nor with anti-DNA antibodies. We report on the induction of SLE in BALB/c mice following immunization with a pathogenic

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## Abstract Twenty‐one sera from 11 patients with systemic lupus erythematosus were titrated with ^125^I‐ss‐calf thymus DNA to determine their maximum capacity to bind DNA. Only five sera were capable of binding > 90% of the input DNA. The remaining sixteen sera showed maximum DNA binding levels be