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Limited Anti-DNA Antibody Specificity in Systemic Lupus Erythematosus

✍ Scribed by Ronald N. Berzofsky; Carole A. Dorsch; Mary Betty Stevens

Publisher
John Wiley and Sons
Year
1977
Tongue
English
Weight
477 KB
Volume
20
Category
Article
ISSN
0004-3591

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✦ Synopsis

Abstract

Twenty‐one sera from 11 patients with systemic lupus erythematosus were titrated with ^125^I‐ss‐calf thymus DNA to determine their maximum capacity to bind DNA. Only five sera were capable of binding > 90% of the input DNA. The remaining sixteen sera showed maximum DNA binding levels between 35% and 85%. The inability of these sera to bind all of the input DNA is shown to be dependent on variations in the molecular weight of the DNA antigen. The possibility that these differences in DNA binding reflect differences in antigenic specificity is discussed.

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