Pathogenic anti-DNA idiotype (16/6 Id) in systemic lupus erythematosus

✍ Scribed by Y. Shoenfeld; E. Mozes

• Book ID: 104714652
• Publisher: Springer
• Year: 1991
• Tongue: English
• Weight: 283 KB
• Volume: 11
• Category: Article
• ISSN: 0172-8172
• DOI: 10.1007/bf00304494

✦ Synopsis

Systemic lupus erythematosus (SLE) is regarded as a classical autoimmune disease. Despite this belief, no one has been able to induce the disease in naive animals, neither with DNA nor with anti-DNA antibodies. We report on the induction of SLE in BALB/c mice following immunization with a pathogenic anti-DNA idiotype (16/6 Id) or its anti-Id. We also report on a specific treatment with T suppressor cells specific for the 16/6 Id. The induction of SLE in naive mice with a pathogenic anti-DNA Id suggests an additional mechanism for the diversity of manifestations in this disease.