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A calculation of percutaneous drug absorption—I. Theoretical

✍ Scribed by Kiyoshi Kubota; Takashi Ishizaki

Publisher
Elsevier Science
Year
1986
Tongue
English
Weight
826 KB
Volume
16
Category
Article
ISSN
0010-4825

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✦ Synopsis

Several theoreticals for simulating percutaneous drug absorption with a computer aid are proposed. By using our theoreticals, the simulation can be made for the process not only during an ointment application but also after its removal. The tlow rate of drug from vehicle to skin and that from skin to blood also be estimated. In addition, we defined an apparent length of diffusion, I, and showed how to assess I,. The effect of a change in regional blood flow on drug flux from the skin at the quasi-steady-state is discussed.

Percutaneous drug absorption Statistical moment theory Pharmacokinetics Diffusion model theory Apparent length of diffusion Mean residence time

Variance of residence of a drug

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