Percutaneous absorption of drugs IV: Percutaneous absorption of drugs from oily vehicles

✍ Scribed by Mitsunori Washitake; Toshio Anmo; Ichiro Tanaka; Takaichi Arita; Masahiro Nakano

• Publisher: John Wiley and Sons
• Year: 1975
• Tongue: English
• Weight: 501 KB
• Volume: 64
• Category: Article
• ISSN: 0022-3549
• DOI: 10.1002/jps.2600640308

✦ Synopsis

The percutaneous absorption and retention of salicylic acid and carbinoxamine from four oily vehicles (liquid paraffin, oleic acid, hexadecyl alcohol, and isopropyl myristate) were studied by employing a recirculation apparatus. The absorption followed first-order kinetics, with the exception of the initial period. The vehicle that had a strong affinity to the drug showed a poor drug-releasing effect, and poor absorption and retention of drugs by the skin were observed. Higher absorption rate constants were observed for damaged skin than intact skin. The acceleration of absorption because of skin damage, however, was not so great from liquid paraffin as from the aqueous solution. The amount of drugs retained in the damaged skin declined following the initial increase.

Keyphrases 0 Salicylic acid in oily vehicles-correlations between in uztro adsorption and in uiuo percutaneous absorption, physicochernical parameters 0 Carbinoxamine in oily vehiclescorrelations between in uitro adsorption and in uiuo percutaneous absorption, physicochemical parameters 0 Vehicles, oily-percutaneous absorption of salicylic acid and carbinoxamine from liquid paraffin, hexadecyl alcohol, oleic acid, and isopropyl myristate Ahsorption, percutaneous-salicylic acid and carbinoxamine from oily vehicle:, intact and damaged skin ' Vaseline.