The permeability coefficient, K p , of pure unbranched alkanoic acids (Cz-C,) applied to isolated porcine skin, reached a maximum in the solubility parameter ( 8 2 ) range of 9.7-10 ~a l ' / ~/ c m ~/ ~. When these and other penetrants were delivered from a solvent vehicle, the following linear rel
Percutaneous absorption of alkanoic acids I: A study of operational conditions
β Scribed by Zvi Liron; Sasson Cohen
- Publisher
- John Wiley and Sons
- Year
- 1984
- Tongue
- English
- Weight
- 501 KB
- Volume
- 73
- Category
- Article
- ISSN
- 0022-3549
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Several theoreticals for simulating percutaneous drug absorption with a computer aid are proposed. By using our theoreticals, the simulation can be made for the process not only during an ointment application but also after its removal. The tlow rate of drug from vehicle to skin and that from skin t
A stainless-steel skin-depot is discussed that may be used during short-term studies to measure directly percutaneous absorption of radiolabeled, volatile chemicals through the skin of unanesthetized, unrestrained hairless mice. The skin-depot is glued to the backs of the mice using cyanoacrylate gl