A Bottom-Up Approach to Build the Hyperpolarizability of Peptides and Proteins from their Amino Acids
✍ Scribed by Duboisset, Julien; Deniset-Besseau, Ariane; Benichou, Emmanuel; Russier-Antoine, Isabelle; Lascoux, Noelle; Jonin, Christian; Hache, François; Schanne-Klein, Marie-Claire; Brevet, Pierre-François
- Book ID
- 121235998
- Publisher
- American Chemical Society
- Year
- 2013
- Tongue
- English
- Weight
- 473 KB
- Volume
- 117
- Category
- Article
- ISSN
- 0022-3654
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A general methodology for the synthesis of saturated lipidic amino acids based on the oxidative cleavage of amino diols obtained by the regioselective opening of enantiomerically enriched 2,3-epoxy alcohols is described. The method opens the way to the synthesis of the enantiomers of lipidic 2-amino
## Abstract A convenient method for the synthesis of phenylmethyl N‐methyl (carboxy‐^14^C) glycine hydrochloride (Z) is described. It involves the carboxylation of transmetalated organostannane compound 4 which itself is accessible by established procedure. Success in preparing the labelled amino a