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9 PS Protease-activated receptor-2 (PAR-2) and mast cell tryptase in irritable bowel syndrome

✍ Scribed by G. Barbara; G. Cottrell; C. Cremon; S. Guerrini; R. De Giorgio; P. Andrade-Gordon; E. Grady; N.W. Bunnett; V. Stanghellini; R. Corinaldesi

Book ID: 119631336
Publisher: Elsevier Science
Year: 2002
Tongue: English
Weight: 150 KB
Volume: 34
Category: Article
ISSN: 1590-8658
DOI: 10.1016/s1590-8658(02)90381-6

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## Background Mast cell (MC)-derived serine proteases have been implicated in a variety of inflammatory processes. We have previously shown that rat peritoneal MC (PMC) express mRNA for protease activated receptor 2 (PAR-2), a G-coupled receptor activated by trypsin-like proteases. Recent evidence