Protease activated receptors (PARs) compose a family of G protein signal transduction receptors activated by proteolysis. In this study, the susceptibility of PARs expressed on human keratinocytes and dermal fibroblasts to the human mast cell proteases tryptase and chymase was evaluated. PAR activat
Distinct expression of mast cell tryptase and protease activated receptor-2 in synovia of rheumatoid arthritis and osteoarthritis
β Scribed by Shunji Nakano; Takuya Mishiro; Shigeyuki Takahara; Hiromichi Yokoi; Daisuke Hamada; Kiminori Yukata; Yoichiro Takata; Tomohiro Goto; Hiroshi Egawa; Susumu Yasuoka; Harumi Furouchi; Katsuya Hirasaka; Takeshi Nikawa; Natsuo Yasui
- Book ID
- 106264804
- Publisher
- Springer
- Year
- 2007
- Tongue
- English
- Weight
- 300 KB
- Volume
- 26
- Category
- Article
- ISSN
- 0770-3198
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## Abstract ## Objective To investigate whether proteaseβactivated receptor 1 (PARβ1) and/or PARβ2 promotes the invasiveness/proliferation of synovial fibroblasts (SFs) and to determine the signaling mechanisms of these pathways. ## Methods SFs were isolated from the synovial tissue of patients
Objective. Protease-activated receptor 2 (PAR-2) activation has been linked to pro-and antiinflammatory cellular responses. We undertook this study to explore the importance of PAR-2 activation in 4 murine models of arthritis and to analyze the expression of PAR-2 in human arthritic synovium. Metho