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9-Hydroxy-9-(4-carboxyphenyl)fluorene — a new linker for solid phase synthesis

✍ Scribed by Bernd Henkel; Ernst Bayer

Publisher
Elsevier Science
Year
1998
Tongue
French
Weight
113 KB
Volume
39
Category
Article
ISSN
0040-4039

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✦ Synopsis

The convenient synthesis of 9-hydroxy-9-(4-carboxyphenyl)fluorene and its application as a new linker for solid phase synthesis is reported. The loading of the resin-bound linker with carboxytic acids as well as the cleavage conditions were investigated. The release of the carboxylic acids from this system by treatment with acids is hampered due to the electron-withdrawing effect of the carboxamide group in the para position of the phenyl ring of the resin-bound linker.

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