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(± )-7α ,8β -dihydroxy-9β ,10β -epoxy-7,8,9,10-tetrahydrobenzo[a]pyrene is an Intermediate in the Metabolism and Binding to DNA of Benzo[a]pyrene

✍ Scribed by H. W. S. King, M. R. Osborne, F. A. Beland, R. G. Harvey and P. Brookes


Book ID
123654032
Publisher
National Academy of Sciences
Year
1976
Tongue
English
Weight
713 KB
Volume
73
Category
Article
ISSN
0027-8424

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The reaction of (±)-7α, 8β-dihydroxy-9β,
✍ M. R. Osborne; P. Brookes; F. A. Beland; R. G. Harvey 📂 Article 📅 1976 🏛 John Wiley and Sons 🌐 French ⚖ 539 KB

## Abstract The reaction of (±)‐7α,8β‐dihydroxy‐9β,10β‐epoxy‐7,8,9,10‐tetrahydrobenzo(__a__)pyrene (BP diol epoxide) with DNA, followed by enzymatic hydrolysis and LH 20 Sephadex column chromatography, yielded products containing a purine deoxyribonucleoside linked to a 7,8,9,10‐tetrahydrobenzo(__a