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6-Thioguanine-related hepatotoxicity in patients with inflammatory bowel disease: Dose or level dependent?

โœ Scribed by Luc J.J. Derijks; Lennard P.L. Gilissen; Nanne K.H. de Boer; Chris J.J. Mulder


Book ID
116651007
Publisher
Elsevier Science
Year
2006
Tongue
English
Weight
51 KB
Volume
44
Category
Article
ISSN
0168-8278

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โœ Ahmed Morales; Sandhya Salguti; Chuan L. Miao; James D. Lewis ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 108 KB

## Background: 6-thioguanine nucleotides (6-tgn) are active metabolites of azathioprine (aza) and 6-mercaptopurine (6mp). higher remission rates have been observed in patients with higher 6-tgn levels. however, many physicians prescribe aza/6mp using milligrams per kilogram (mg/kg) dosing regimens