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A systematic survey evaluating 6-thioguanine-related hepatotoxicity in patients with inflammatory bowel disease

โœ Scribed by Alexander Teml; Matthias Schwab; Daan W. Hommes; Sven Almer; Milan Lukas; Thomas Feichtenschlager; Timothy Florin; Julia Seiderer; Wolfgang Petritsch; Bernd Bokemeyer; Wolfgang Kreisel; Klaus R. Herrlinger; Peter Knoflach; Bruno Bonaz; Thomas Klugmann; Hans Herfarth; Nikolaus Pedarnig; Walter Reinisch

Book ID
106172261
Publisher
Springer Vienna
Year
2007
Tongue
English
Weight
156 KB
Volume
119
Category
Article
ISSN
0043-5325

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Relationship between 6-mercaptopurine do
Relationship between 6-mercaptopurine dose and 6-Thioguanine nucleotide levels in patients with inflammatory bowel disease
โœ Ahmed Morales; Sandhya Salguti; Chuan L. Miao; James D. Lewis ๐Ÿ“‚ Article ๐Ÿ“… 2007 ๐Ÿ› John Wiley and Sons ๐ŸŒ English โš– 108 KB

## Background: 6-thioguanine nucleotides (6-tgn) are active metabolites of azathioprine (aza) and 6-mercaptopurine (6mp). higher remission rates have been observed in patients with higher 6-tgn levels. however, many physicians prescribe aza/6mp using milligrams per kilogram (mg/kg) dosing regimens