6-Methyl penicillins and 7-methyl cephalosporins
โ Scribed by Boehme, E. H. W.; Applegate, H. E.; Toeplitz, B.; Dolfini, J. E.; Gougoutas, J. Z.
- Book ID
- 127171266
- Publisher
- American Chemical Society
- Year
- 1971
- Tongue
- English
- Weight
- 414 KB
- Volume
- 93
- Category
- Article
- ISSN
- 0002-7863
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๐ SIMILAR VOLUMES
The theory that penicillins and cephalosporins are D-alanyl-D-alanine surrogates led Strominger and Tipper (2) to predict that placing a methyl group in the same position as is found in the D-alanyl residue, i.e. a to the lactam carbonyl, would increase antibacterial effectiveness.
A series of 6-(carboxymethylene)penicillinates and 7-(carboxymethylene)cephalosporanates were synthesized and evaluated as inhibitors of one type A and two type C p-lactamases. Disodium 6-(carboxymethylene)penicillinate sulfone (15) showed broad spectrum activity. A kinetic analysis demonstrated tha
The acid catalyzed ring expansion (1) of penicillin sulfoxide esters, 1, to deacetoxy cephalosporins, 2, has assumed added importance due to the demonstrated oral effectiveness of the broad-spectrum antibiotic, cephalexin (2). We now wish to report additional studies that further aid in elucidating