Substituted penicillins and cephalosporins II. C-6(7)-alkyl derivatives (1)

✍ Scribed by Raymond A. Firestone; Natalie Schelechow; David B.R. Johnston; B.G. Christensen

• Book ID: 104236405
• Publisher: Elsevier Science
• Year: 1972
• Tongue: French
• Weight: 195 KB
• Volume: 13
• Category: Article
• ISSN: 0040-4039
• DOI: 10.1016/s0040-4039(01)84328-8

✦ Synopsis

The theory that penicillins and cephalosporins are D-alanyl-D-alanine surrogates led Strominger and Tipper (2) to predict that placing a methyl group in the same position as is found in the D-alanyl residue, i.e. a to the lactam carbonyl, would increase antibacterial effectiveness.