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Substituted penicillins and cephalosporins V. 6(7)-substituted alkyl derivatives

✍ Scribed by David B.R. Johnston; Susan M. Schmitt; Raymond A. Firestone; B.G. Christensen

Book ID
104245546
Publisher
Elsevier Science
Year
1972
Tongue
French
Weight
194 KB
Volume
13
Category
Article
ISSN
0040-4039

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πŸ“œ SIMILAR VOLUMES

Substituted penicillins and cephalospori
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✍ Raymond A. Firestone; Natalie Schelechow; David B.R. Johnston; B.G. Christensen πŸ“‚ Article πŸ“… 1972 πŸ› Elsevier Science 🌐 French βš– 195 KB

The theory that penicillins and cephalosporins are D-alanyl-D-alanine surrogates led Strominger and Tipper (2) to predict that placing a methyl group in the same position as is found in the D-alanyl residue, i.e. a to the lactam carbonyl, would increase antibacterial effectiveness.

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A simple N-substituted formamido penicillin was found to differ in rate and mode of decomposition from its unsubstituted counterpart. A series of derivatives were prepared and their antibacterial properties examined.