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6α-(N-substituted formamido) penicillins and derivatives

✍ Scribed by Alison C Brown; Angela W Guest; Peter H Milner

Book ID
104232863
Publisher
Elsevier Science
Year
1989
Tongue
French
Weight
253 KB
Volume
30
Category
Article
ISSN
0040-4039

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✦ Synopsis

A simple N-substituted formamido penicillin was found to differ in rate and mode of decomposition from its unsubstituted counterpart. A series of derivatives were prepared and their antibacterial properties examined.

📜 SIMILAR VOLUMES

Substituted penicillins and cephalospori
Substituted penicillins and cephalosporins II. C-6(7)-alkyl derivatives (1)
✍ Raymond A. Firestone; Natalie Schelechow; David B.R. Johnston; B.G. Christensen 📂 Article 📅 1972 🏛 Elsevier Science 🌐 French ⚖ 195 KB

The theory that penicillins and cephalosporins are D-alanyl-D-alanine surrogates led Strominger and Tipper (2) to predict that placing a methyl group in the same position as is found in the D-alanyl residue, i.e. a to the lactam carbonyl, would increase antibacterial effectiveness.

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✍ Angela W Guest 📂 Article 📅 1986 🏛 Elsevier Science 🌐 French ⚖ 219 KB

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