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The synthesis and lactamase inhibitory activity of 6-(carboxymethylene)penicillins and 7-(carboxymethylene)cephalosporins

✍ Scribed by John D. Buynak; Bolin Geng; Brian Bachmann; Ling Hua

Book ID: 103982987
Publisher: Elsevier Science
Year: 1995
Tongue: English
Weight: 259 KB
Volume: 5
Category: Article
ISSN: 0960-894X
DOI: 10.1016/0960-894x(95)00249-s

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✦ Synopsis

A series of 6-(carboxymethylene)penicillinates and 7-(carboxymethylene)cephalosporanates were synthesized and evaluated as inhibitors of one type A and two type C p-lactamases. Disodium 6-(carboxymethylene)penicillinate sulfone (15) showed broad spectrum activity. A kinetic analysis demonstrated that 15 was a potent, partially irreversible inhibitor of the 13-1actamase derived from Enterobacter cloacae Ix)9.

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