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Synthesis and β-lactamase inhibitory activity of 6-hydroxyethyl thiaclavulanic acid.

✍ Scribed by Walter Cabri; Angelo Bedeschi; Ettore Perrone; Giuseppina Visentin; Daniela Jabes; Franceschi Giovanni

Book ID
108477048
Publisher
Elsevier Science
Year
1993
Tongue
English
Weight
289 KB
Volume
3
Category
Article
ISSN
0960-894X

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✍ John D. Buynak; Bolin Geng; Brian Bachmann; Ling Hua 📂 Article 📅 1995 🏛 Elsevier Science 🌐 English ⚖ 259 KB

A series of 6-(carboxymethylene)penicillinates and 7-(carboxymethylene)cephalosporanates were synthesized and evaluated as inhibitors of one type A and two type C p-lactamases. Disodium 6-(carboxymethylene)penicillinate sulfone (15) showed broad spectrum activity. A kinetic analysis demonstrated tha