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599 Promoter hypermethylation of hMLH1 gene in liver fluke related cholangiocarcinoma

โœ Scribed by T. Limpaiboon; P. Khaenam; M. Soonklang; P. Jearanaikoon; B. Sripa; V. Bhuhisawasdi; C. Pairojkul


Book ID
118620772
Publisher
Elsevier Science
Year
2003
Tongue
English
Weight
168 KB
Volume
1
Category
Article
ISSN
1359-6349

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Age-related hypermethylation of the hMLH
โœ Tomoko Nakajima; Yoshimitsu Akiyama; Junichi Shiraishi; Tomio Arai; Yuka Yanagis ๐Ÿ“‚ Article ๐Ÿ“… 2001 ๐Ÿ› John Wiley and Sons ๐ŸŒ French โš– 94 KB

To determine whether methylation of the hMLH1 promoter is related to increasing age and gastric carcinogenesis, we examined hMLH1 methylation and expression in 100 gastric cancers. hMLH1 methylation and aberrant protein expression were observed in 9 and 13 cancers, respectively. Normal and intestina