## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in
✦ LIBER ✦
5-I A-85380 and TC-2559 differentially activate heterologously expressed α4β2 nicotinic receptors
✍ Scribed by Ruud Zwart; Lisa M. Broad; Qian Xi; Martin Lee; Mirko Moroni; Isabel Bermudez; Emanuele Sher
- Book ID
- 113586135
- Publisher
- Elsevier Science
- Year
- 2006
- Tongue
- English
- Weight
- 214 KB
- Volume
- 539
- Category
- Article
- ISSN
- 0014-2999
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## Abstract Nicotine activates specific receptors that are cation‐permeable ionic channels located in the central and autonomous nervous systems, as well as at the neuromuscular junction. Administration of nicotine to animals and humans has been shown to enhance cognitive processes. However, side e