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Stimulation of the α4β2 nicotinic receptor by 5-I A-85380 improves auditory gating in DBA/2 mice

✍ Scribed by Kristin M. Wildeboer; Karen E. Stevens

Book ID
113503597
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
693 KB
Volume
1224
Category
Article
ISSN
0006-8993

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## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in