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SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380

✍ Scribed by Sally L. Pimlott; Margaret Piggott; James Patterson; Jonathan Cavanagh; David J. Wyper

Publisher
John Wiley and Sons
Year
2007
Tongue
French
Weight
153 KB
Volume
50
Category
Article
ISSN
0022-2135

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✦ Synopsis

Abstract

In order to image nAChR density in vivo in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, in vitro validation in human post‐mortem tissue and some initial in vivo clinical studies using the ligand [5‐^123/125^I]A85380. Limitations of the usefulness of the tracer for routine clinical use are also discussed. Copyright © 2007 John Wiley & Sons, Ltd.

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