✦ LIBER ✦

Quantification of nicotinic acetylcholine receptors in human brain using [123I]5-I-A-85380 SPET

✍ Scribed by Masahiro Fujita; Masanori Ichise; ChristopherH. Dyck; SamiS. Zoghbi; Gilles Tamagnan; AlexeyG. Mukhin; Ali Bozkurt; Nicholas Seneca; Dnyanesh Tipre; ChristopherC. DeNucci; Hidehiro Iida; D.Bruce Vaupel; AndrewG. Horti; AndreiO. Koren; AlaneS. Kimes; EdytheD. London; JohnP. Seibyl; RonaldM. Baldwin; RobertB. Innis

Publisher: Springer
Year: 2003
Tongue: English
Weight: 314 KB
Volume: 30
Category: Article
ISSN: 0340-6997
DOI: 10.1007/s00259-003-1320-0

No coin nor oath required. For personal study only.

📜 SIMILAR VOLUMES

Whole-body biodistribution, radiation ab

Whole-body biodistribution, radiation absorbed dose, and brain SPET imaging with [123I]5-I-A-85380 in healthy human subjects

✍ Masahiro Fujita, John P. Seibyl, Bruce D. Vaupel, Gilles Tamagnan, Michele Early 📂 Article 📅 2001 🏛 Springer 🌐 English ⚖ 127 KB

SPECT imaging of the α4β2 nicotinic rece

SPECT imaging of the α4β2 nicotinic receptor using [5-123I]A85380

✍ Sally L. Pimlott; Margaret Piggott; James Patterson; Jonathan Cavanagh; David J. 📂 Article 📅 2007 🏛 John Wiley and Sons 🌐 French ⚖ 153 KB

## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in

Pharmacology, toxicology, and radiation

Pharmacology, toxicology, and radiation dosimetry evaluation of [123I]5-I-A-85380, a radioligand for in vivo imaging of cerebral neuronal nicotinic acetylcholine receptors in humans

✍ D. Bruce Vaupel; Srihari R. Tella; David L. Huso; Alexey G. Mukhin; Ira Baum; Va 📂 Article 📅 2003 🏛 John Wiley and Sons 🌐 English ⚖ 269 KB

[125/123I]IPH: A radioiodinated analog o

[125/123I]IPH: A radioiodinated analog of epibatidine for in vivo studies of nicotinic acetylcholine receptors

✍ John L. Musachio; Victor L. Villemagne; Ursula Scheffel; Marigo Stathis; Paige F 📂 Article 📅 1997 🏛 John Wiley and Sons 🌐 English ⚖ 180 KB 👁 1 views

Tomographic imaging of central nicotinic acetylcholine receptors (nAChRs) via single photon emission computed tomography (SPECT) has been hampered by the lack of a radioligand with suitable in vivo binding characteristics. Therefore, a novel analog of epibatidine, (6)-exo-2-(2-iodo-5-pyridyl)-7-azab

Dissociation between duration of action

Dissociation between duration of action in the forced swim test in mice and nicotinic acetylcholine receptor occupancy with sazetidine, varenicline, and 5-I-A85380

✍ Barbara J. Caldarone; Daguang Wang; Neil E. Paterson; Michael Manzano; Allison F 📂 Article 📅 2011 🏛 Springer 🌐 English ⚖ 459 KB

In vivo binding of [123I]4-(2′-methoxy p

In vivo binding of [123I]4-(2′-methoxy phenyl)-1-[2′-(N-2″-pyridinyl)-P-iodobenzamido-]ethyl-piperazine, p-MPPI, to 5-HT1A receptors in rat brain

✍ Mei-Ping Kung; Zhi-Ping Zhuang; Dana Frederick; Hank F. Kung 📂 Article 📅 1994 🏛 John Wiley and Sons 🌐 English ⚖ 862 KB

The in vivo regional distribution and pharmacological profile of a novel iodinated phenylpiperazine derivative, [12311p-MPPI (4-(2'-methoxy-)phenyl-l-[2'-(N-2"pyridinyl)-p-iodobenzamido-Iethyl-piperazine), in the rat brain were evaluated for use as a potential in vivo imaging agent for 5-HTlA recept