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5-123I-A-85380 binding to the α4β2-nicotinic receptor in mild cognitive impairment

✍ Scribed by Emma Terrière; Mary F. Dempsey; Lucie L. Herrmann; Kevin M. Tierney; Jane A. Lonie; Ronan E. O’Carroll; Sally Pimlott; David J. Wyper; Karl Herholz; Klaus P. Ebmeier

Book ID
116781426
Publisher
Elsevier Science
Year
2010
Tongue
English
Weight
394 KB
Volume
31
Category
Article
ISSN
0197-4580

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## Abstract In order to image nAChR density __in vivo__ in humans, [5‐^123^I]‐iodo‐3‐[2(S)‐2‐azetidinylmethoxy]pyridine ([5‐^123^I]A85380) has been developed as a SPECT imaging tracer. This article outlines the radiochemical synthesis, __in vitro__ validation in human post‐mortem tissue and some in