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5′-Deoxy-5′-thioribonucleoside-5′-triphosphates

✍ Scribed by Bhisma Kumar Patel; Fritz Eckstein

Book ID: 104256457
Publisher: Elsevier Science
Year: 1997
Tongue: French
Weight: 246 KB
Volume: 38
Category: Article
ISSN: 0040-4039
DOI: 10.1016/s0040-4039(97)00084-1

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✦ Synopsis

5"-Deoxy-5"-thiouridine-and 5"-deoxy-5"-thioadenosine-5"-triphosphate 6 and 7 were chemically synthesised by two methods. Their incorporation into RNA to produce a 5"-S-bridging phosphorothioate internucleotide linkages, using T7 RNA polymerase, was investigated.

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