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Recognition of 2′-Deoxy-l-ribonucleoside 5′-Triphosphates by Human Telomerase

✍ Scribed by Toyofumi Yamaguchi; Rieko Yamada; Aki Tomikawa; Koichi Shudo; Motoki Saito; Fuyuki Ishikawa; Mineo Saneyoshi

Book ID
115587057
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
373 KB
Volume
279
Category
Article
ISSN
0006-291X

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Inhibition of Human Telomerase by 7-Deaz
Inhibition of Human Telomerase by 7-Deaza-2′-deoxyguanosine Nucleoside Triphosphate Analogs: Potent Inhibition by 6-Thio-7-deaza-2′-deoxyguanosine 5′-Triphosphate
✍ Terace M. Fletcher; Brian E. Cathers; K.S. Ravikumar; Blain M. Mamiya; Sean M. K 📂 Article 📅 2001 🏛 Elsevier Science 🌐 English ⚖ 487 KB

We have examined analogs of the previously reported 7-deaza-2Ј-deoxypurine nucleoside triphosphate series of human telomerase inhibitors. Two new telomerase-inhibiting nucleotides are reported: 6-methoxy-7-deaza-2Ј-deoxyguanosine 5Ј-triphosphate (OMDG-TP) and 6-thio-7-deaza-2Ј-deoxyguanosine 5Ј-trip