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5-Bromo-2'-deoxycytidine (BCDR)-I. Studies on metabolism in vitro and in mice

✍ Scribed by William H. Prusoff; John W. Cramer; Ming Y. Chu; Arnold D. Welch


Book ID
115767521
Publisher
Elsevier Science
Year
1961
Tongue
English
Weight
255 KB
Volume
8
Category
Article
ISSN
0006-2952

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Phase I study on 5-aza-2β€²-deoxycytidine
✍ Georges E. Rivard; Richard L. Momparler; Jocelyn Demers; Paul Benoit; Richard Ra πŸ“‚ Article πŸ“… 1981 πŸ› Elsevier Science 🌐 English βš– 709 KB

Ahstract--A Phase I study with 5-aza-2'-deoxycytidine (5-AZA-CdR) was performed on children with acute leukemia who were resistant to conventional chemotherapy. The objective of this study was to find the dose-schedule of 5-AZA-CdR that produced a potent antileukemic effect and to evaluate its toxic