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Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia

✍ Scribed by Georges E. Rivard; Richard L. Momparler; Jocelyn Demers; Paul Benoit; Richard Raymond; Kun-Tsan Lin; Louise F. Momparler

Book ID
113238078
Publisher
Elsevier Science
Year
1981
Tongue
English
Weight
709 KB
Volume
5
Category
Article
ISSN
0145-2126

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Phase I study on 5-aza-2′-deoxycytidine
Phase I study on 5-aza-2′-deoxycytidine in children with acute leukemia
✍ Georges E. Rivard; Richard L. Momparler; Jocelyn Demers; Paul Benoit; Richard Ra 📂 Article 📅 1981 🏛 Elsevier Science 🌐 English ⚖ 709 KB

Ahstract--A Phase I study with 5-aza-2'-deoxycytidine (5-AZA-CdR) was performed on children with acute leukemia who were resistant to conventional chemotherapy. The objective of this study was to find the dose-schedule of 5-AZA-CdR that produced a potent antileukemic effect and to evaluate its toxic