Clinical trial on 5-AZA-2′-deoxycytidine in patients with acute leukemia
✍ Scribed by Richard L. Momparler; Georges E. Rivard; Martin Gyger
- Book ID
- 118385385
- Publisher
- Elsevier Science
- Year
- 1985
- Tongue
- English
- Weight
- 749 KB
- Volume
- 30
- Category
- Article
- ISSN
- 0163-7258
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Ahstract--A Phase I study with 5-aza-2'-deoxycytidine (5-AZA-CdR) was performed on children with acute leukemia who were resistant to conventional chemotherapy. The objective of this study was to find the dose-schedule of 5-AZA-CdR that produced a potent antileukemic effect and to evaluate its toxic
## Abstract ## BACKGROUND General and site‐specific DNA methylation is associated with tumor progression and resistance in several cancers, including chronic myelogenous leukemia (CML). Decitabine is a hypomethylating agent that has shown encouraging preliminary anti‐CML activity. This study evalu