4,4-Disubstituted Piperidine High-Affinity NK 1 Antagonists: Structure−Activity Relationships and in Vivo Activity
✍ Scribed by Stevenson, Graeme I.; Huscroft, Ian; MacLeod, Angus M.; Swain, Christopher J.; Cascieri, Margaret A.; Chicchi, Gary G.; Graham, Michael I.; Harrison, Timothy; Kelleher, Fintan J.; Kurtz, Marc; Ladduwahetty, Tamara; Merchant, Kevin J.; Metzger, Joseph M.; MacIntyre, D. E.; Sadowski, Sharon; Sohal, Balbinder; Owens, Andrew P.
- Book ID
- 121338293
- Publisher
- American Chemical Society
- Year
- 1998
- Tongue
- English
- Weight
- 256 KB
- Volume
- 41
- Category
- Article
- ISSN
- 0022-2623
No coin nor oath required. For personal study only.
📜 SIMILAR VOLUMES
Structure-activity relationships (SAR) of analogues of lead compound 1 were investigated and compound 16 was selected for further study in animal models of pain. Compound 16 was shown to be a potent antihyperalgesic agent in both the rat acute complete Freund's adjuvant (CFA) model of inflammatory p