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425 Structure Activity Relationship of a Novel Chemical Class of Microtubule-disrupting Agents

✍ Scribed by Desire, L.; Casagrande, A.S.; Bachelot, F.; Coutadeur, S.; Maurier-Mahe, F.; Leblond, B.; Beausoleil, E.; Taverne, T.; Chauvignac, C.; Pando, M.

Book ID: 123502883
Publisher: Elsevier Science
Year: 2012
Tongue: English
Weight: 55 KB
Volume: 48
Category: Article
ISSN: 0959-8049
DOI: 10.1016/S0959-8049(12)72223-2

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## Abstract Based on a novel lead compound 4‐methylpiperazine‐1‐carbodithioic acid 3‐cyano‐3,3‐diphenylpropyl ester **1**, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their __in‐vitro__ anticancer activities on four to six different cell