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Benzoylurea Derivatives as a Novel Class of Antimitotic Agents: Synthesis, Anticancer Activity, and Structure−Activity Relationships

✍ Scribed by Song, Dan-Qing; Wang, Yan; Wu, Lian-Zong; Yang, Peng; Wang, Yue-Ming; Gao, Li-Mei; Li, Yan; Qu, Jing-Rong; Wang, Yong-Hong; Li, Ying-Hong; Du, Na-Na; Han, Yan-Xing; Zhang, Zhi-Ping; Jiang, Jian-Dong

Book ID: 120576369
Publisher: American Chemical Society
Year: 2008
Tongue: English
Weight: 275 KB
Volume: 51
Category: Article
ISSN: 0022-2623
DOI: 10.1021/jm070890u

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## Abstract Based on a novel lead compound 4‐methylpiperazine‐1‐carbodithioic acid 3‐cyano‐3,3‐diphenylpropyl ester **1**, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their __in‐vitro__ anticancer activities on four to six different cell