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Synthesis and structure−activity relationship of 8-substituted protoberberine derivatives as a novel class of antitubercular agents

✍ Scribed by Ying-Hong Li, Hai-Gen Fu, Feng Su, Li-Mei Gao, Sheng Tang…

Book ID: 120704308
Publisher: Chemistry Central
Year: 2013
Tongue: English
Weight: 215 KB
Volume: 7
Category: Article
ISSN: 1752-153X
DOI: 10.1186/1752-153X-7-117

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## Abstract Based on a novel lead compound 4‐methylpiperazine‐1‐carbodithioic acid 3‐cyano‐3,3‐diphenylpropyl ester **1**, the systematic structural modification was carried out. All the synthesized compounds were evaluated for their __in‐vitro__ anticancer activities on four to six different cell