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417: A consanguineous family with Frontotemporal Dementia/Motor Neuron Disease

✍ Scribed by Clement T. Loy; Bill S. Brooks; Kevin Taddei; A. Patton; Catriona McLean; Glenda M. Halliday; Ralph Martins; John B. Kwok; Peter R. Schofield


Book ID
116674425
Publisher
Elsevier Science
Year
2008
Tongue
English
Weight
56 KB
Volume
15
Category
Article
ISSN
0967-5868

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It has been recently demonstrated that the 43-kDa transactive response (TAR)-DNA-binding protein (TARDBP) is the neuropathological hallmark of Frontotemporal Dementia (FTD) with ubiquitin-positive and tau-negative inclusions. Large series of FTD patients without motor neuron disease have been previo