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[3H]1-[2-(4-Aminophenyl)Ethyl]-4-(3-Trifluoromethylphenyl)Piperazine: A Selective Radioligand for 5-HT1A Receptors in Rat Brain

✍ Scribed by Richard W. Ransom; Kenneth B. Asarch; Jean C. Shih


Book ID
111173923
Publisher
John Wiley and Sons
Year
1986
Tongue
English
Weight
767 KB
Volume
46
Category
Article
ISSN
0022-3042

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2-[4-(o-methoxyphenyl)piperazin-1-ylmeth
✍ MarΓ­a L. LΓ³pez-RodrΓ­guez; MaJosΓ© Morcillo; MaLuisa Rosado; Bellinda Benhamu; Ant πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 246 KB

A series of 2-[~-(4-arylpiperazin-1-yl)aikyl]-1,3-dioxoperhydroimidazo[ 1,5-a]pyridine derivatives was prepared and evaluated for affinity at 5-HT~A and ct I receptors. The most promising analogue Ira bound at 5-HT~A sites with nanomolar affinity (/~.=31.7) and high selectivity over ~, D2 and 5-HT2A