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2-[4-(3,4-Dimethylphenyl)piperazin-1-ylmethyl]-1H benzoimidazole (A-381393), a selective dopamine D4 receptor antagonist

✍ Scribed by Masaki Nakane; Marlon D. Cowart; Gin C. Hsieh; Loan Miller; Marie E. Uchic; Renjie Chang; Marc A. Terranova; Diana L. Donnelly-Roberts; Marian T. Namovic; Thomas R. Miller; Jill M. Wetter; Kennan Marsh; Andrew O. Stewart; Jorge D. Brioni; Robert B. Moreland


Book ID
116784312
Publisher
Elsevier Science
Year
2005
Tongue
English
Weight
300 KB
Volume
49
Category
Article
ISSN
0028-3908

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2-[4-(o-methoxyphenyl)piperazin-1-ylmeth
✍ MarΓ­a L. LΓ³pez-RodrΓ­guez; MaJosΓ© Morcillo; MaLuisa Rosado; Bellinda Benhamu; Ant πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 246 KB

A series of 2-[~-(4-arylpiperazin-1-yl)aikyl]-1,3-dioxoperhydroimidazo[ 1,5-a]pyridine derivatives was prepared and evaluated for affinity at 5-HT~A and ct I receptors. The most promising analogue Ira bound at 5-HT~A sites with nanomolar affinity (/~.=31.7) and high selectivity over ~, D2 and 5-HT2A