A series of 2-[~-(4-arylpiperazin-1-yl)aikyl]-1,3-dioxoperhydroimidazo[ 1,5-a]pyridine derivatives was prepared and evaluated for affinity at 5-HT~A and ct I receptors. The most promising analogue Ira bound at 5-HT~A sites with nanomolar affinity (/~.=31.7) and high selectivity over ~, D2 and 5-HT2A
β¦ LIBER β¦
ChemInform Abstract: 2-(4-(o-Methoxyphenyl)piperazin-1-ylmethyl)-1,3-dioxoperhydroimidazo(1, 5-a)pyridine as a New Selective 5-HT1A Receptor Ligand.
β Scribed by M. L. LOPEZ-RODRIGUEZ; M. J. MORCILLO; M. L. ROSADO; B. BENHAMU; A. M. SANZ
- Book ID
- 112034699
- Publisher
- John Wiley and Sons
- Year
- 2010
- Weight
- 33 KB
- Volume
- 27
- Category
- Article
- ISSN
- 0931-7597
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