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ChemInform Abstract: Synthesis and Structure-Activity Relationships of a New Model of Arylpiperazines. Part 1. 2-((4-(o-Methoxyphenyl)piperazin-1-yl)methyl)- 1,3-dioxoperhydroimidazo(1,5-a)pyridine: A Selective 5-HT1A Receptor Agonist.

✍ Scribed by M. L. LOPEZ-RODRIGUEZ; M. L. ROSADO; B. BENHAMU; M. J. MORCILLO; A. M. SANZ; L. ORENSANZ; M. E. BENEITEZ; J. A. FUENTES; J. MANZANARES

Publisher
John Wiley and Sons
Year
2010
Weight
34 KB
Volume
28
Category
Article
ISSN
0931-7597

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## 1-[Ο‰-(4-Arylpiperazin-1-yl)alkyl] -3-diphenylmethylene-2,5pyrrolidinediones as 5-HT 1A Receptor Ligands: Study of the Steric Requirements of the Terminal Amide Fragment on 5-HT 1A Affinity/Selectivity. -Two different methods are used to prepare the desired title compounds (IV) and (VII) which