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3'-(Arylmethyl)- and 3'-(Aryloxy)-3-phenyl-4-hydroxyquinolin- 2(1H)-ones: Orally Active Antagonists of the Glycine Site on the NMDA Receptor

✍ Scribed by Kulagowski, Janusz J.; Baker, Raymond; Curtis, Neil R.; Mawer, Ian M.; Moseley, Angela M.; Ridgill, Mark P.; Rowley, Michael; Stansfield, Ian; Leeson, Paul D.


Book ID
118270950
Publisher
American Chemical Society
Year
1994
Tongue
English
Weight
479 KB
Volume
37
Category
Article
ISSN
0022-2623

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πŸ“œ SIMILAR VOLUMES


3-Hydroxy-quinolin-2-ones: Inhibitors of
✍ Sing-Yuen Sit; Frederick J. Ehrgott; Jinnian Gao; Nicholas A. Meanwell πŸ“‚ Article πŸ“… 1996 πŸ› Elsevier Science 🌐 English βš– 294 KB

A series of substituted 3-hydroxy-quinolin-2-one derivatives 6 was synthesized and evaluated as inhibitors of [3H]-glycine and [3H]-AMPA binding to rat cortical membranes. These compounds were generally found to be more potent ligands for the NMDA-associated glycine binding site than the AMPA recept