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ChemInform Abstract: 3-Hydroxyquinolin-2-ones: Inhibitors of (3H)-Glycine Binding to the Site Associated with the NMDA Receptor.

โœ Scribed by S.-Y. SIT; F. J. EHRGOTT; J. GAO; N. A. MEANWELL

Book ID
112034386
Publisher
John Wiley and Sons
Year
2010
Weight
30 KB
Volume
27
Category
Article
ISSN
0931-7597

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3-Hydroxy-quinolin-2-ones: Inhibitors of
3-Hydroxy-quinolin-2-ones: Inhibitors of [3H]-glycine binding to the site associated with the NMDA receptor
โœ Sing-Yuen Sit; Frederick J. Ehrgott; Jinnian Gao; Nicholas A. Meanwell ๐Ÿ“‚ Article ๐Ÿ“… 1996 ๐Ÿ› Elsevier Science ๐ŸŒ English โš– 294 KB

A series of substituted 3-hydroxy-quinolin-2-one derivatives 6 was synthesized and evaluated as inhibitors of [3H]-glycine and [3H]-AMPA binding to rat cortical membranes. These compounds were generally found to be more potent ligands for the NMDA-associated glycine binding site than the AMPA recept