Genetic instability related to defective DNA mismatch repair genes may be involved in the pathogenesis of carcinoma in Hereditary Non-Polyposis Colorectal Cancer (HN-PCC). To test that the targets of genetic instability could include critical transforming genes involved in colon tumor progression, w
26 P Beta-catenin, p53 and K-ras mutations in faeces of colorectal carcinoma patients
β Scribed by M. Notarnicola; A. Cavallini; A. Di Leo
- Book ID
- 119631222
- Publisher
- Elsevier Science
- Year
- 2002
- Tongue
- English
- Weight
- 154 KB
- Volume
- 34
- Category
- Article
- ISSN
- 1590-8658
No coin nor oath required. For personal study only.
π SIMILAR VOLUMES
Aberrant crypt foci (ACF) are putative precursor lesions of colon cancer, recently identified on the methylene blue-stained mucosal surface of human colon. No mutations in K-vas or p53 genes were found by non-radioactive single-strand conformation polymorphism analysis in 14 ACF collected from five
## Abstract Gene mutations in __APC__, __Kβras__, and __p53__ are thought to be essential events for colorectal cancer development. Recent data seem to indicate that __Kβras__ and __p53__ mutations rarely coβexist in the same tumor, indicating that these alterations do not represent a synergistic e