Mutant-enriched PCR was applied to the detection of mutations at codons I 2 and I 3 of K-ras genes in the stools of patients with colorectal cancer. Mutations were analyzed in stool samples obtained prior to surgery. Resected tumor specimens were screened for K-ras mutations by PCR-mediated RFLP ana
Detection of K-ras/p53 mutations in stool specimens of patients with colorectal cancer
β Scribed by Hattori, Takashi; Kaminaga, Norihiro; Endo, Yutaka; Hiroshi, Takahashi; Fujita, Rikiya
- Book ID
- 122661430
- Publisher
- Elsevier Science
- Year
- 1998
- Tongue
- English
- Weight
- 180 KB
- Volume
- 114
- Category
- Article
- ISSN
- 0016-5085
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## Abstract Gene mutations in __APC__, __Kβras__, and __p53__ are thought to be essential events for colorectal cancer development. Recent data seem to indicate that __Kβras__ and __p53__ mutations rarely coβexist in the same tumor, indicating that these alterations do not represent a synergistic e