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Heterogeneity of p53 gene and k-ras gene in colorectal carcinoma

✍ Scribed by Akifumi Kuwabara; Yoichi Ajioka; Hidenobu Watanabe; Katsuyoshi Hatakeyama


Book ID
119425387
Publisher
Elsevier Science
Year
2000
Tongue
English
Weight
176 KB
Volume
118
Category
Article
ISSN
0016-5085

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## Abstract Gene mutations in __APC__, __K‐ras__, and __p53__ are thought to be essential events for colorectal cancer development. Recent data seem to indicate that __K‐ras__ and __p53__ mutations rarely co‐exist in the same tumor, indicating that these alterations do not represent a synergistic e