2,4-Dihydro-3H-1,2,4-triazole-3-thiones as potential antidepressant agents
✍ Scribed by Kane, John M.; Dudley, Mark W.; Sorensen, Stephen M.; Miller, Francis P.
- Book ID
- 111962146
- Publisher
- American Chemical Society
- Year
- 1988
- Tongue
- English
- Weight
- 816 KB
- Volume
- 31
- Category
- Article
- ISSN
- 0022-2623
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## Abstract magnified image Various 4‐amino‐2,3‐dihydro‐4__H__‐triazoles with aromatic, aliphatic and heterocyclic substituents at the C(5) position were synthesized from corresponding esters and thiocarbohydrazide. This method allows the synthesis these heterocycles in a short time and at reduced
The acyclic C=N double bond of the title compound, C~10~H~10~N~4~S, is __trans__ configured. The molecule is almost planar. The angle between the two rings is just 10.25 (7)°. The crystal packing is stabilized by N—H...S hydrogen bonds and π–π interactions.
In the title compound, C 18 H 15 OPÁC 10 H 12 N 4 OS, the triazole ring makes a dihedral angle of 51.24 (7) with the attached benzene ring. The triazole ring and its thione substituent are delocalized. There are intermolecular N-HÁ Á ÁO and N-HÁ Á ÁS hydrogen bonds, which also involve the cocrystall