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2,2,2-Trifluoroacetamidins as new trifluoromethyl building blocks for fluorinated nitrogen heterocycles

โœ Scribed by Kenji Uneyama; Koji Sugimoto; Osamu Morimoto; Fumio Yamashita; Masashi Kobayashi

Book ID
104150304
Publisher
Elsevier Science
Year
1991
Tongue
English
Weight
40 KB
Volume
54
Category
Article
ISSN
0022-1139

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โœฆ Synopsis

2,2,2-Trifluoroacetimidoyl chlorides 1 are much more stable than the corresponding nonfluorinated chlorides because of the deactivation for hydrolysis by the strong electronwithdrawing fluorine atom and thus useful as synthetic blocks.

They react smoothly with nucleophilics such as Grignard reagents, active methylene compounds, and primary amines.

2,2,2-Trifluotoacetamidines 2 are promising precursors for CFg-containing heterocycles as shown in the scheme.

Preparations and reactions of 2 are discussed in

๐Ÿ“œ SIMILAR VOLUMES

Trifluoroacetimidoyl chlorides as a new
Trifluoroacetimidoyl chlorides as a new trifluoromethyl building block for fluorinated nitrogen heterocycles
โœ Kenji Uneyama; Osamu Morimoto; Fumio Yamashita ๐Ÿ“‚ Article ๐Ÿ“… 1989 ๐Ÿ› Elsevier Science ๐ŸŒ French โš– 210 KB

N-Substituted trifluoroacetimidoyl chlorides have been prepared and allowed to react with various carbon nucleophiles, affording trifluoromethyl ketimines. Organofluorine compounds have accepted an increasing attentions.') Among them, preparations of trifluoromethylated compounds are in great demand